Development and validation of the Surgical Outcome Risk Tool (SORT).

Existing risk stratification tools have limitations and clinical experience suggests they are not used routinely. The aim of this study was to develop and validate a preoperative risk stratification tool to predict 30-day mortality after non-cardiac surgery in adults by analysis of data from the observational National Confidential Enquiry into Patient Outcome and Death (NCEPOD) Knowing the Risk study

A collective scattering system for measuring electron gyroscale fluctuations on the National Spherical Torus Experiment

A collective scattering system has been installed on the National Spherical Torus Experiment (NSTX) to measure electron gyroscale fluctuations in NSTX plasmas. The system measures fluctuations with k(perpendicular to)rho(e)less than or similar to 0.6 and k(perpendicular to)less than or similar to 20 cm(-1). Up to five distinct wavenumbers are measured simultaneously, and the large toroidal curvature of NSTX plasmas provides enhanced spatial localization. Steerable optics can position the scattering volume throughout the plasma from the magnetic axis to the outboard edge. Initial measurements indicate rich turbulent dynamics on the electron gyroscale. The system will be a valuable tool for investigating the connection between electron temperature gradient turbulence and electron thermal transport in NSTX plasmas.X1137sciescopu

Anxiety, Movement Kinematics, and Visual Attention in Elite-Level Performers

We tested the predictions of Attentional Control Theory (ACT) by examining the effect of anxiety on attention control and the subsequent influence on both performance effectiveness and performance efficiency within a perceptual-motor context. A sample (N = 16) of elite shotgun shooters was tested under counterbalanced low (practice) and high (competition) anxiety conditions. A head-mounted, corneal reflection system allowed point of gaze to be calculated in relation to the scene, while motion of the gun was evaluated using markers placed on the barrel which were captured by two stationary cameras and analyzed using optical tracking software. The quiet eye (QE) duration and onset were analyzed along with gun barrel displacement and variability; performance outcome scores (successful vs. unsuccessful) were also recorded. QE (Vickers, 1996) is defined as the final fixation or tracking gaze that is located on a specific location/object in the visual display for a minimum of 100 ms. Longer QE durations have been linked to successful performance in previous research involving aiming tasks. Participants demonstrated shorter quiet eye durations, and less efficient gun motion, along with a decreased performance outcome (fewer successful trials) under high compared with low anxiety conditions. The data support the predictions of ACT with anxiety disrupting control processes such that goal-directed attention was compromised, leading to a significant impairment in performance effectiveness

The Desirability Bias In Predictions: Going Optimistic Without Leaving Realism

Does desire for an outcome inflate optimism? Previous experiments have produced mixed resultsregarding the desirability bias, with the bulk of supportive findings coming from one paradigm—the classic marked-card paradigm in which people make discrete predictions about desirable orundesirable cards being drawn from decks. We introduce a biased-guessing account for the effects from this paradigm, which posits that people are often realistic in their likelihood assessments, but when making a subjectively arbitrary prediction (a guess), they will tend to guess in a desired direction. In order to establish the validity of the biased-guessing account and to distinguish it from other accounts, we conducted five experiments that tested the desirability bias within the paradigm and novel extensions of it. In addition to supporting the biased-guessing account, the findings illustrate the critical role of moderators (e.g., type of outcome, type of forecast) for fully understanding and predicting desirability biases

Who, What, When, Where, And Why? A New Story Of Journalism, As Told By Nonprofit News Organizations

Communication scholars and professional journalists have used genres in recent years to propose solutions to social and financial crises that continuously plague the field in a digital age. One of these emerging genres is nonprofit journalism, which, with claims of transparency and a dedication to the “public interest” has established a strong following by the public and professionals since 2010. In part, the trust of the public has also been restored through nonprofit news organizations placing them at the forefront of the drama of journalism, as actors and changemakers. As audiences are invited into a new worldview of the field of journalism, its scene, agency, and purpose, this thesis explores exactly what story is being told, and what repercussions it may have for the drama of journalism as a whole. By rethinking the role of journalism from informer to changemaker, professionals in the field may risk crossing a definitional boundary from journalist to activist

Upregulation Of Inducible Nitric Oxide Synthase Contributes To Attenuated Cutaneous Vasodilation In Essential Hypertensive Humans

Essential hypertension is a proinflammatory, proconstrictor disease coinciding with endothelial dysfunction and inward vessel remodeling. Using the skin circulation, our aim was to determine whether inducible NO synthase (iNOS) upregulation attenuates NO-dependent cutaneous vasodilation in hypertensive humans. We hypothesized that, with hypertension, localized iNOS inhibition would restore vasodilation in response to NO-dependent stimuli, and iNOS expression would be increased and phosphorylated vasodilator-stimulated phosphoprotein would be decreased. For, in vivo protocols, 4 intradermal microdialysis fibers were placed in 9 hypertensive and 10 normotensive men and women (systolic blood pressure: 146±4 versus 113±2 mm Hg; P<0.001). Microdialysis fibers served as control, iNOS inhibited (1400 W), neuronal NO synthase inhibited (N?-propyl-l-arginine), and nonselective NOS inhibited (NG-nitro-l-arginine methyl ester). Cutaneous vascular conductance was calculated (percentage of sodium nitroprusside) during standardized local heating (42°C) and acetylcholine dose-response protocols (0.01, 0.10, 1.00, 5.00, 10.00, 50.00, 100.00 mmol/L). The NO-dependent local heating response was attenuated at control (95±2% versus 76±2% cutaneous vascular conductance; P<0.05) and neuronal NO synthase–inhibited sites (94±4% versus 77±3% cutaneous vascular conductance; P<0.01) in hypertensives. iNOS inhibition augmented the NO-dependent local heating response (93±2% versus 89±10% cutaneous vascular conductance). Acetylcholine-induced vasodilation was attenuated in control sites at doses =0.1 mmol/L of acetylcholine in hypertensives and was restored with iNOS inhibition (0.1 mmol/L, P<0.05; 1, 5, and 10 mmol/L, P<0.001; 50 and 100 mmol/L, P<0.01). In vitro iNOS expression was increased (P=0.006) and phosphorylated vasodilator-stimulated phosphoprotein was decreased in skin from hypertensive humans (P=0.04). These data suggest that iNOS is upregulated in essential hypertensive humans and contributes to reduced NO-dependent cutaneous vasodilation

Sources Of Bias In Peoples' Social-Comparative Estimates Of Food Consumption

Understanding how healthfully people think they eat compared to others has implications for their motivation to engage in dietary change and the adoption of health recommendations. Our goal was to investigate the scope, sources, and measurements of bias in comparative food consumption beliefs. Across 4 experiments, participants made direct comparisons of how their consumption compared to their peers’ consumption and/or estimated their personal consumption of various foods/nutrients and the consumption by peers, allowing the measurement of indirect comparisons. Critically, the healthiness and commonness of the foods varied. When the commonness and healthiness of foods both varied, indirect comparative estimates were more affected by the healthiness of the food, suggesting a role for self-serving motivations, while direct comparisons were more affected by the commonness of the food, suggesting egocentrism as a nonmotivated source of comparative bias. When commonness did not vary, the healthiness of the foods impacted both direct and indirect comparisons, with a greater influence on indirect comparisons. These results suggest that both motivated and nonmotivated sources of bias should be taken into account when creating interventions aimed at improving eating habits and highlights the need for researchers to be sensitive to how they measure perceptions of comparative eating habits

The Influence of Ambiguity and Uncertainty on Wishful Thinking

People are confronted with situations where they have to make choices and judgments every day. In making decisions, people may have a preference for one option over another, and the wishful thinking effect describes their increased optimism and inflation of the likelihood of that option happening. This phenomena has been illustrated in a variety of different contexts, including sporting events and drawing cards from a deck. Further research into the wishful thinking effect illustrates that the greatest amount of this desirability bias is exhibited in situations where the most uncertainty is present. This study expands upon previous research by including the variable of ambiguity, or “uncertainty about uncertainty”. I hypothesized that in situations that were more ambiguous, participants would display a greater amount of wishful thinking. To test this, I manipulated the uncertainty, ambiguity, and desirability of two-color square grids and asked participants to make predictions about which color they believed the computer would choose at random. Contrary to my hypothesis, I found that the greater amount of ambiguity, the less wishful thinking they exhibited, and in conditions where there was no ambiguity, participants exhibited the greatest amount of wishful thinking

Skipping Years and Scribal Errors: Kaqchikel Maya timekeeping in the fifteenth, sixteenth, and seventeenth centuries

Adrian Recinos's correlation of Kaqchikcl Maya and Spanish dates in the Annals of the Kaqchikels contains n umerous errors. and there are several scribal and calculation errors in how both the 260-day and 400-day Kaqchikel Maya calendars were used within the manuscript. These are dating problems that stem from errors by the scribes in their attempt to adapt to a European counting and documentation system and their inexperience with the Kaqchikel Maya calendars. In addition, unique citation marks and two scribal errors shed light on the existence of earlier documents and subsequent effects on the later time counts of the Kaqchikcl Maya calendar system. This paper adjusts the previous correlation by Recinos and extends it from 1 570 until 1603. Moreover, by highlighting and correcting the internal errors, this paper offers a caveat to scholars when reconstructing the histories, events, and social relations of past Mesoamerican peoples and scripts without regard for internal errors

Responses To Hyperthermia. Optimizing Heat Dissipation By Convection And Evaporation: Neural Control Of Skin Blood Flow And Sweating In Humans

Under normothermic, resting conditions, humans dissipate heat from the body at a rate approximately equal to heat production. Small discrepancies between heat production and heat elimination would, over time, lead to significant changes in heat storage and body temperature. When heat production or environmental temperature is high the challenge of maintaining heat balance is much greater. This matching of heat elimination with heat production is a function of the skin circulation facilitating heat transport to the body surface and sweating, enabling evaporative heat loss. These processes are manifestations of the autonomic control of cutaneous vasomotor and sudomotor functions and form the basis of this review. We focus on these systems in the responses to hyperthermia. In particular, the cutaneous vascular responses to heat stress and the current understanding of the neurovascular mechanisms involved. The available research regarding cutaneous active vasodilation and vasoconstriction is highlighted, with emphasis on active vasodilation as a major responder to heat stress. Involvement of the vasoconstrictor and active vasodilator controls of the skin circulation in the context of heat stress and nonthermoregulatory reflexes (blood pressure, exercise) are also considered. Autonomic involvement in the cutaneous vascular responses to direct heating and cooling of the skin are also discussed. We examine the autonomic control of sweating, including cholinergic and noncholinergic mechanisms, the local control of sweating, thermoregulatory and nonthermoregulatory reflex control and the possible relationship between sudomotor and cutaneous vasodilator function. Finally, we comment on the clinical relevance of these control schemes in conditions of autonomic dysfunction